16α-Hydroxylation of steroids with gel-entrapped Streptomyces roseochromogenes cells in water-organic cosolvent system
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چکیده
منابع مشابه
Microbial hydroxylation of 16α, 17α-epoxyprogesterone by Penicillium decumbens
Microbial transformation has been successfully applied in the production of steroid intermediates with therapeutic use and commercial value in pharmaceutical industry due to its high regio- and stereo-selectivity. As such, it is still important to screen microbial strains with novel activity or more efficient abilities in the development of the commercial steroid industry. Biotransformation of ...
متن کاملMicrobial hydroxylation of 16α, 17α-epoxyprogesterone by Penicillium decumbens
Microbial transformation has been successfully applied in the production of steroid intermediates with therapeutic use and commercial value in pharmaceutical industry due to its high regio- and stereo-selectivity. As such, it is still important to screen microbial strains with novel activity or more efficient abilities in the development of the commercial steroid industry. Biotransformation of ...
متن کاملRegio- and stereospecific hydroxylation of various steroids at the 16α position of the D ring by the Streptomyces griseus cytochrome P450 CYP154C3.
Cytochrome P450 monooxygenases (P450s), which constitute a superfamily of heme-containing proteins, catalyze the direct oxidation of a variety of compounds in a regio- and stereospecific manner; therefore, they are promising catalysts for use in the oxyfunctionalization of chemicals. In the course of our comprehensive substrate screening for all 27 putative P450s encoded by the Streptomyces gri...
متن کاملMicrobial Hydroxylation of 16α, 17α-Epoxyprogesterone by Penicillium Decumbens
Microbial transformation has been successfully applied in the production of steroid intermediates with therapeutic use and commercial value in pharmaceutical industry due to its high regio- and stereo-selectivity. As such, it is still important to screen microbial strains with novel activity or more efficient abilities in the development of the commercial steroid industry. Biotransformation of ...
متن کاملEnzymology in aqueous-organic cosolvent binary mixtures.
The theory and results of solvent structure control on solute behavior for ordinary chemical reactions, generated in other laboratories (e.g. by Arnett and colleagues), were applied to enzyme reactions in water-organic cosolvent binary mixtures. Three kinds of reactions were studied: (a) catalysis of substrate reactions; (b) denaturation, judged by loss of overall activity; (c) renaturation, ai...
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ژورنال
عنوان ژورنال: NIPPON KAGAKU KAISHI
سال: 1983
ISSN: 2185-0925,0369-4577
DOI: 10.1246/nikkashi.1983.1393